izindaba

Ngokusekelwe kuhlaka lwamathambo lwe-aza-BODIPY, i-NIR1001 ihlanganisa amaqembu anikela ngama-electron (isb, 4-N,N-diphenylaminophenyl) ezindaweni ezingu-2,6, okwenza ukwakheka kwe-D-π-D1 kwe-symmetric. Lo mklamo unciphisa igebe le-HOMO-LUMO, ugudluze inani eliphakeme lokumunca libe ngaphezu kwe-1000 nm futhi uthuthukise ukudluliswa kwe-intramolecular charge (ICT). Ku-THF, i-NIR1001 ibonisa isigaba esiphezulu sokumuncwa kwezithombe ezimbili (TPA) esingu-37 GM, ukuthuthuka okuphindwe kabili kunokuphuma kokuphuma kwendabuko kwe-BODIPY. Isikhathi sokuphila sayo sesimo esijabulile esingu-1.2 ps senza uguquko olusebenzayo olungasebenzisi imisebe, luyenze ifanelekele ukwelashwa kwe-photodynamic (PDT).

Izibalo ze-DFT zembula ukuthi indlela yokudlulisa inkokhiso ye-NIR1001 ivela ku-π-electron delocalization phakathi kwezingxenye zomnikeli nomamukeli. Ukuguqulwa kwe-Methoxy kuthuthukisa futhi ukumuncwa kwe-NIR efasiteleni le-phototherapeutic (650-900 nm), kuthuthukisa ukuzwela1. Uma kuqhathaniswa nodayi be-AF baseFudan University, i-NIR1001 igcina isisindo samangqamuzana esincane (<500 Da) esinokuthatha izithombe ngo-40%. Ukuguqulwa kwe-carboxylation kuthuthukisa ukuncibilika kwamanzi (cLogD=1.2), kunciphisa ukukhangiswa okungaqondile ezinhlelweni zebhayoloji

3. Izicelo Zezokwelapha
Ku-bioimaging, i-hCG-conjugated probe hCG-NIR1001 ifinyelela isithombe sokucaca okuphezulu kwama-ovarian follicles nama-micro-metastases ngaphansi kwe-808 nm excitation. Ngokujula kokungena okungu-3 cm ku-NIR-II, idlula ama-NIR-I probe ngokuphindwe kathathu, kuyilapho inciphisa i-fluorescence yangemuva ngo-60%. Kumodeli yokulimala kwezinso zegundane, i-NIR1001 ibonisa u-85% wokuthatha okuqondene nezinso, ithola umonakalo ngokushesha okuphindwe kasithupha kunezilawuli ze-macromolecular.
Ku-PDT, i-NIR1001 ikhiqiza izinhlobo ze-oxygen esebenzayo (i-ROS) ku-0.85 μmol/J ngaphansi kwe-laser irradiation engu-1064 nm, okwenza ngempumelelo i-tumor cell apoptosis. I-NIR1001 nanoparticles (NPs) efakwe i-Liposome-encapsulated iqongelela izikhathi ezingu-7.2 ngaphezulu kumathumba kunodayi wamahhala, inciphisa imithelela engahlosiwe.
4. Ukuqapha Izimboni Nezemvelo
Kuzinhlelo zokusebenza zezimboni, i-NIR1001 ihlanganiswe ku-Juhang Technology's SupNIR-1000 analyzer ukuze kuhlungwe izithelo, kuhlolwe izinga lenyama, kanye nokucutshungulwa kukagwayi. Isebenza ku-900-1700 nm ububanzi, ngesikhathi esifanayo ikala okuqukethwe ushukela, umswakama, nezinsalela zezibulala-zinambuzane phakathi kwamasekhondi angu-30 ngokunemba ±(50ppm+5%). Kuzinzwa ze-CO2 zezimoto (ACDS-1001), i-NIR1001 inika amandla ukuqapha kwesikhathi sangempela nge-T90≤25s isikhathi sokuphendula kanye neminyaka engu-15 yokuphila.
Ukuze kutholwe imvelo, ama-NIR1001-functionalized probe athola izinsimbi ezisindayo emanzini. Ku-pH 6.5-8.0, ukushuba kwe-fluorescence kuhlobana ngokuqondile nokugxilisana kwe-Hg²⁺ (0.1-10 μM) ngomkhawulo wokutholwa ongu-0.05 μM, izindlela zombala ezisebenza kahle kakhulu ngama-oda amabili obukhulu.
5. Ukuqamba Okusha Kwezobuchwepheshe kanye Nezohwebo
I-Qingdao Topwell Materialsisebenzisa ukuhlanganiswa okuqhubekayo ukukhiqiza i-NIR1001 ekuhlanzekeni okungama-99.5%, nomthamo we-50 kg/batch. Ngokusebenzisa ama-microchannel reactors, isikhathi se-Knoevenagel condensation sincishiswa sisuka emahoreni ayi-12 siye kumizuzu engama-30, sinciphisa ukusetshenziswa kwamandla ngo-60%. Uchungechunge lwe-ISO 13485-certified NIR1001 lulawula imakethe ye-biomedical.